Phenotypes Associated with This Genotype

Genotype
MGI:6263527

• Allelic Composition: Smg1^{tm1b(EUCOMM)Hmgu}/Smg1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Smg1^{tm1b(EUCOMM)Hmgu}/Wtsi
• Cell Lines: HEPD0860_6_F10

Data Sources

IMPC Data for Smg1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment at E9.5

• biased differentiation (diploid/polyploid trophoblast)

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:261316 )

• fewer than the expected numbers of embryos are obtained at E9.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

lethality throughout fetal growth and development, complete penetrance ( J:261316 )

• complete lethality at E14.5