Phenotypes Associated with This Genotype

Genotype
MGI:6263189

• Allelic Composition: Pmpcb^{tm1b(EUCOMM)Hmgu}/Pmpcb^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Pmpcb^{tm1b(EUCOMM)Hmgu}/Bay
• Cell Lines: HEPD0778_6_A10

Data Sources

IMPC Data for Pmpcb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Pmpcb^{tm1b(EUCOMM)Hmgu}/Pmpcb^{tm1b(EUCOMM)Hmgu} mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as blastocysts, hatch from the zona pellucida, and form normal outgrowths in culture with very compact inner cell mass.

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - BCM

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM

embryonic lethality between implantation and somite formation, complete penetrance ( J:290315 , J:279207 )

• normal looking blastocysts are present at E3.5 (15% versus expected 25%, n=40); excess resorption sites but no homozygous embryos are observed at E7.5 (J:279207)

• in vitro, blastocysts hatch from the zona pellucida and form morphological normal outgrowth colonies with very compact inner cell mass (ICM) colonies after 3 days in culture (J:279207)