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Phenotypes Associated with This Genotype
Genotype
MGI:6259179
Allelic
Composition
Tg(Eno2-Thrsp)#Cheo/0
Genetic
Background
C57BL/6-Tg(Eno2-Thrsp)#Cheo
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the Y-maze, mice show no differences in the total number of arm entries, however they exhibit a lower percentage of spontaneous alternation indicating impaired attention
• methylphenidate treated mice show increased spontaneous alternation in the Y-maze
• however, mice do not show locomotor alternation, impulsive behavior, anxiety, or motor-balance impairment
• in the novel-object recognition test, mice show a lower investigation time and discrimination index indicating impaired attention
• mice treated with methylphenidate show improved investigation time and enhanced discrimination index in the novel-object recognition test

nervous system
• mice show elevated striatal dopaminergic-related gene expression that is normalized with methylphenidate treatment


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory