Phenotypes Associated with This Genotype

Genotype
MGI:6258927

• Allelic Composition: Pold3^em1Linl/Pold3^em1Linl
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:263620 )

• mice die between E4.5 and E7.5

embryo

abnormal trophoblast giant cell proliferation ( J:263620 )

• reduced proliferation during blastocyst outgrowth

absent egg cylinders ( J:263620 )

abnormal embryonic tissue physiology ( J:263620 )

• in culture, inner cell mass fail to expand unlike wild-type cells

• increased apoptosis during blastocyst outgrowth

decreased inner cell mass proliferation ( J:263620 )

cellular

decreased inner cell mass proliferation ( J:263620 )

abnormal trophoblast giant cell proliferation ( J:263620 )

• reduced proliferation during blastocyst outgrowth