Phenotypes Associated with This Genotype

Genotype
MGI:6258420

• Allelic Composition: Tg(KRT5-Terf2)PMBlas/Y; Tg(KRT5-Tert)8043Blas/0
• Genetic Background: involves: C57BL/6 * CBA * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

increased skin pigmentation ( J:102653 )

• double mutant mice exhibit skin hyperpigmentation in response to light, similar to single Tg(KRT5-Terf2)PMBlas mutant mice

integument

increased skin pigmentation ( J:102653 )

• double mutant mice exhibit skin hyperpigmentation in response to light, similar to single Tg(KRT5-Terf2)PMBlas mutant mice

cellular

decreased telomere length ( J:102653 )

• double mutant mice exhibit short telomeres in tail skin, similar to single Tg(KRT5-Terf2)PMBlas mutant mice, indicating that critically short telomeres are not rescued by telomerase overexpression