Phenotypes Associated with This Genotype

Genotype
MGI:6258419

• Allelic Composition: Tg(KRT5-Terf2)PNBlas/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:102653 )

N • mice are born with normal Mendelian distribution, unlike Tg(KRT5-Terf2)PMBlas transgenic males

pigmentation

increased ear pigmentation ( J:102653 )

• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice

increased foot pigmentation ( J:102653 )

• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice

increased tail pigmentation ( J:102653 )

• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice

increased skin pigmentation ( J:102653 )

• mice exhibit mild hyperpigmentation of light-exposed skin areas (tail, paws and ear) relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice

integument

increased ear pigmentation ( J:102653 )

• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice

increased foot pigmentation ( J:102653 )

• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice

increased tail pigmentation ( J:102653 )

• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice

increased skin pigmentation ( J:102653 )

• mice exhibit mild hyperpigmentation of light-exposed skin areas (tail, paws and ear) relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice

cellular

decreased telomere length ( J:102653 )

• at 4 months of age, mice exhibit markedly shorter telomeres in tail skin than age-matched wild-type controls

neoplasm

neoplasm ( J:102653 )

N • older mice do NOT develop spontaneous tumors in light-exposed areas of the skin, such as the tail

craniofacial

increased ear pigmentation ( J:102653 )

• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice

growth/size/body

increased ear pigmentation ( J:102653 )

• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice

hearing/vestibular/ear

increased ear pigmentation ( J:102653 )

• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice

limbs/digits/tail

increased tail pigmentation ( J:102653 )

• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice