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Phenotypes Associated with This Genotype
Genotype
MGI:6256831
Allelic
Composition
Trpv4tm1c(KOMP)Wtsi/Trpv4tm1c(KOMP)Wtsi
Tg(GFAP-cre)25Mes/0
Genetic
Background
involves: C57BL/6J * C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(GFAP-cre)25Mes mutation (2 available)
Trpv4tm1c(KOMP)Wtsi mutation (1 available); any Trpv4 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• after region-specific injection of hyaluronic acid to induce acute retinal detachment (RD), Mueller cells exhibit 50% less cell death and fail to exhibit significant mechanical stimuli-evoked current or inward current and HC067047 did not have an inhibitory effect unlike in wild-type Mueller cells
• however, retina subjected to RD exhibit normal gliosis and increased proliferation


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory