Phenotypes Associated with This Genotype

Genotype
MGI:6241340

• Allelic Composition: Bcl2^tm1Sjk/Bcl2^tm1Sjk; Tg(Dct-lacZ)A12Jkn/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal melanoblast morphology ( J:157070 )

• mice show complete loss of LacZ+ melanoblasts in the bulge area at the end stage of hair follicle morphogenesis (i.e. stage 8, but not stage 6), indicating apoptosis of bulge melanocyte stem cells; in contrast, pigmented melanocytes are still maintained in the bulb at stage 8

• mice treated with an anti-TGF-beta blocking antibody during the process of stem cell entry to the dormant state (stage 5-8) exhibit increased survival (rescue) of bulge LacZ+ melanoblasts at P4, P6, and P8, whereas untreated mice or mice treated with a control antibody display virtual loss of LacZ+ melanoblasts from the bulge area by P8

nervous system

abnormal melanoblast morphology ( J:157070 )

• mice show complete loss of LacZ+ melanoblasts in the bulge area at the end stage of hair follicle morphogenesis (i.e. stage 8, but not stage 6), indicating apoptosis of bulge melanocyte stem cells; in contrast, pigmented melanocytes are still maintained in the bulb at stage 8

• mice treated with an anti-TGF-beta blocking antibody during the process of stem cell entry to the dormant state (stage 5-8) exhibit increased survival (rescue) of bulge LacZ+ melanoblasts at P4, P6, and P8, whereas untreated mice or mice treated with a control antibody display virtual loss of LacZ+ melanoblasts from the bulge area by P8