Phenotypes Associated with This Genotype

Genotype
MGI:6220403

• Allelic Composition: Hsp90b1^tm1Zhli/Hsp90b1^tm1Zhli; Tg(Tyr-cre/ERT2)13Bos/0
• Genetic Background: B6.Cg-Tg(Tyr-cre/ERT2)13Bos Hsp90b1^tm1Zhli

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal hair follicle melanogenesis ( J:265851 )

• mice show decreased levels of melanin in hair bulbs in the 4-OHT-treated area relative to control mice

reduced hair shaft melanin granule number ( J:265851 )

• mice show decreased levels of melanin in hair shafts plucked from the 4-OHT-treated area relative to control mice

diluted coat color ( J:265851 )

• following 4 weeks of topical application of 4-hydroxytamoxifen (4-OHT) to shaved skin on the right flank, coat hair that re-grows in the 4-OHT-treated area is grey/white in color, whereas hair re-grown in the vehicle (ethanol)-treated left flank is black; control mice treated with either 4-OHT or vehicle show no change in hair color

integument

abnormal hair follicle melanogenesis ( J:265851 )

• mice show decreased levels of melanin in hair bulbs in the 4-OHT-treated area relative to control mice

reduced hair shaft melanin granule number ( J:265851 )

• mice show decreased levels of melanin in hair shafts plucked from the 4-OHT-treated area relative to control mice

diluted coat color ( J:265851 )

• following 4 weeks of topical application of 4-hydroxytamoxifen (4-OHT) to shaved skin on the right flank, coat hair that re-grows in the 4-OHT-treated area is grey/white in color, whereas hair re-grown in the vehicle (ethanol)-treated left flank is black; control mice treated with either 4-OHT or vehicle show no change in hair color