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Phenotypes Associated with This Genotype
Genotype
MGI:6202042
Allelic
Composition		 Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Slc3a1tm1Jat/Slc3a1tm1Jat
Genetic
Background		 involves: 129 * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfe2l2tm1Ywk mutation (2 available); any Nfe2l2 mutation (90 available)
Slc3a1tm1Jat mutation (0 available); any Slc3a1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
cystolithiasis ( J:254803 )
• rate of stone growth is similar to that in single Slc3a1 homozygotes
• treatment with alpha-lipoic acid suppresses stone growth as seen in single Slc3a1 homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory