Analysis Tools
behavior/neurological
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• in a nerve lesion model induced by chronic constriction injury of the left sciatic nerve, mutants do not show reduced mechanical allodynia after decompression as is seen in wild-type mice
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• mice treated with oxaliplatin to induce cold allodynia exhibit more severe cold allodynia in the recovery phase of treatment than wild-type mice
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• mice exhibit aggravated EAE-induced nociceptive behaviors than control mice, with mice being hypersensitive to nonnociceptive cold stimulus at 15 degrees C, including shortening the latency to the first nocifensive behavior and increased nocifensive events
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cellular
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• axon outgrowth of dorsal root ganglion neurons is often in a single direction and followed by few dynamic growth cones indicating that pathfinding of axon outgrowth is affected
• the velocities of axon extension and retraction are slower in dorsal root ganglia neurons
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immune system
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• mice exhibit aggravated EAE-induced nociceptive behaviors than control mice, with mice being hypersensitive to nonnociceptive cold stimulus at 15 degrees C, including shortening the latency to the first nocifensive behavior and increased nocifensive events
• mice exhibit abnormal EAE-induced neural plasticity mainly in IB4+ central projections, with partially disrupted IB4+ dorsal horn layers in the mediolateral extent of lamina II and increased CGRP- and IB4-labeled overlapping region
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nervous system
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• axon outgrowth of dorsal root ganglion neurons is often in a single direction and followed by few dynamic growth cones indicating that pathfinding of axon outgrowth is affected
• the velocities of axon extension and retraction are slower in dorsal root ganglia neurons
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• dorsal root ganglion neurons show reduced neurite length and neurite branching
• axon regeneration is affected in IB4+ but not CGRP+ neurons, with postponed or halted neurite outgrowth of IB4+ dorsal root ganglia neurons
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• dorsal root ganglion neurons show reduced neurite length and neurite branching
• accumulation of myosin IIa in lamellipodia of growth cones of cultured dorsal root ganglia neurons is lower
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