About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6200372
Allelic
Composition		 Ly96m1Btlr/Ly96m1Btlr
Genetic
Background		 C57BL/6J-Ly96m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ly96m1Btlr mutation (0 available); any Ly96 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased macrophage apoptosis ( J:265259 )
• decrease in LPS-induced macrophage necroptosis
decreased interleukin-1 beta secretion ( J:265259 )
• peritoneal macrophages isolated from pique homozygous mice secreted reduced amounts of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed bynigericin treatment
decreased tumor necrosis factor secretion ( J:265259 )
• from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

cellular
decreased macrophage apoptosis ( J:265259 )
• decrease in LPS-induced macrophage necroptosis

hematopoietic system
decreased macrophage apoptosis ( J:265259 )
• decrease in LPS-induced macrophage necroptosis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
07/22/2025
MGI 6.24 		The Jackson Laboratory