Phenotypes Associated with This Genotype

Genotype
MGI:6200051

• Allelic Composition: Nlrp1a^m1Btlr/Nlrp1a^m1Btlr
• Genetic Background: C57BL/6J-Nlrp1a^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased macrophage apoptosis ( J:265173 )

• in response to LPS was increased

decreased B cell number ( J:265173 )

• of B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood

decreased B-1 B cell number ( J:265173 )

decreased B-1b cell number ( J:265173 )

decreased B-2 B cell number ( J:265173 )

decreased NK cell number ( J:265173 )

increased effector memory CD8-positive, alpha-beta T cell number ( J:265173 )

decreased T cell number ( J:265173 )

decreased CD8-positive, alpha-beta T cell number ( J:265173 )

decreased central memory CD8 positive, alpha-beta T cell number ( J:265173 )

decreased single-positive T cell number ( J:265173 )

increased IgE level ( J:265173 )

• in the serum

increased tumor necrosis factor secretion ( J:265173 )

• in response to the TLR7 ligand R848

growth/size/body

decreased body weight ( J:265173 )

cellular

increased macrophage apoptosis ( J:265173 )

• in response to LPS was increased

hematopoietic system

increased macrophage apoptosis ( J:265173 )

• in response to LPS was increased

decreased B cell number ( J:265173 )

• of B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood

decreased B-1 B cell number ( J:265173 )

decreased B-1b cell number ( J:265173 )

decreased B-2 B cell number ( J:265173 )

decreased NK cell number ( J:265173 )

increased effector memory CD8-positive, alpha-beta T cell number ( J:265173 )

decreased T cell number ( J:265173 )

decreased CD8-positive, alpha-beta T cell number ( J:265173 )

decreased central memory CD8 positive, alpha-beta T cell number ( J:265173 )

decreased single-positive T cell number ( J:265173 )

increased IgE level ( J:265173 )

• in the serum