Phenotypes Associated with This Genotype

Genotype
MGI:6199634

• Allelic Composition: Bcl10^m1Btlr/Bcl10^m1Btlr
• Genetic Background: C57BL/6J-Bcl10^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B-1 B cell number ( J:265122 )

increased T cell number ( J:265122 )

increased CD4-positive, alpha-beta T cell number ( J:265122 )

increased single-positive T cell number ( J:265122 )

increased IgE level ( J:265122 )

• in the serum

• serum levels of total IgE and OVA-specific IgE are elevated after administration of ovalbumin

decreased IgG level ( J:265122 )

• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll

increased IgM level ( J:265122 )

• on the surface of peripheral blood B cells

immune system

decreased B-1 B cell number ( J:265122 )

increased T cell number ( J:265122 )

increased CD4-positive, alpha-beta T cell number ( J:265122 )

increased single-positive T cell number ( J:265122 )

abnormal humoral immune response ( J:265122 )

• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll

increased IgE level ( J:265122 )

• in the serum

• serum levels of total IgE and OVA-specific IgE are elevated after administration of ovalbumin

decreased IgG level ( J:265122 )

• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll

increased IgM level ( J:265122 )

• on the surface of peripheral blood B cells