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Phenotypes Associated with This Genotype
Genotype
MGI:6198752
Allelic
Composition
Zfp462Tn(pb-Act-RFP)1.090115023-HRAZhu/Zfp462+
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp462Tn(pb-Act-RFP)1.090115023-HRAZhu mutation (0 available); any Zfp462 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• no defects in memory or movement
• spend more time in the closed arm of an elevated plus maze
• in an open field test mice spend less time in the inside area and have fewer center entries
• spend less time in the light compartment and make fewer light-dark transitions in a light-dark box test
• bury more marbles in a marble burying assay
• treatment with imipramine attenuates anxiety-like behaviors
• increased grooming time and number of grooming bouts
• treatment with imipramine attenuates excessive self-grooming

nervous system

integument
• hair loss that is aggravated with age with 15% and 30% of mice showing hair loss at 4 and 6 months of age

growth/size/body
• from P1 to 2 months of age
• delayed growth from P1 to 2 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
generalized anxiety disorder DOID:14320 J:262219


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory