Phenotypes Associated with This Genotype

Genotype
MGI:6198555

• Allelic Composition: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0; Trem2^{tm1(KOMP)Vlcg}/Trem2⁺
• Genetic Background: involves: C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased myeloid cell number ( J:264653 )

• mice show a reduction in the number of plaque-associated myeloid cells compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice, indicating an impairment in myeloid cell accumulation around plaques

abnormal hematopoietic system physiology ( J:264653 )

• proliferation of myeloid cells is reduced compared to levels in single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

homeostasis/metabolism

amyloid beta deposits ( J:264653 )

• mice exhibit a modest increase in the total cortical plaque number and percent area compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

• mice show an increase in soluble amyloid beta 1-40 in the hippocampus compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

nervous system

amyloid beta deposits ( J:264653 )

• mice exhibit a modest increase in the total cortical plaque number and percent area compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

• mice show an increase in soluble amyloid beta 1-40 in the hippocampus compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

abnormal neurite morphology ( J:264653 )

• marker analysis indicates increased plaque-associated neuritic dystrophy compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice