Phenotypes for Met Sftpc MGI:6197801 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Met^tm1Sst/Met^tm1Sst Sftpc^{tm1(cre/ERT2,rtTA)Hap}/Sftpc⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Met^tm1Sst mutation (1 available); any Met mutation (81 available)
Sftpc^{tm1(cre/ERT2,rtTA)Hap} mutation (0 available); any Sftpc mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal pulmonary alveolus morphology ( J:264185 )

• tamoxifen-treated mice show reduced density of alveoli

overexpanded pulmonary alveolus ( J:264185 )

• alveoli are enlarged in tamoxifen-treated mice

emphysema ( J:264185 )

• adult mice treated with tamoxifen exhibit enlargement of alveolar airspace and loss of alveolar density, indicating emphysematous changes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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