Phenotypes Associated with This Genotype

Genotype
MGI:6197065

• Allelic Composition: Lrrtm3^tm1Msa/Lrrtm3^tm1Msa
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased dendritic spine density ( J:263400 )

• in dentate gyrus granule neurons

• modestly reduced of the number of dendritic spines of asymmetric/excitatory synapses in middle molecular layer at P14

• however, excitatory synapse density is normal in CA1 pyramidal neurons and the number of GABA+ presynaptic boutons is normal

abnormal action potential ( J:263400 )

• lower firing rate of dentate granule neurons

• however, CA1 pyramidal neurons exhibit normal firing rates

abnormal CNS synaptic transmission ( J:263400 )

• however, maximal response is normal

• small decrease in evoked excitatory synaptic transmission

decreased excitatory postsynaptic current amplitude ( J:263400 )

• in dentate gyrus granule cells

abnormal miniature excitatory postsynaptic currents ( J:263400 )

• reduced amplitude with increased frequency in dentate gyrus granule cells

• however, miniature miniature inhibitory postsynaptic current frequency and amplitude are normal

abnormal synaptic depression ( J:263400 )

• faster depression of evoked EPSC amplitude

decreased paired-pulse facilitation ( J:263400 )