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Phenotypes Associated with This Genotype
Genotype
MGI:6196878
Allelic
Composition		 Rubcnem1Dgre/Rubcnem1Dgre
Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * C57BL/6N * C57BL/6NCrlj * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rubcnem1Dgre mutation (1 available); any Rubcn mutation (39 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal macrophage morphology ( J:261225 )
• increased numbers of LC3 (Map1lc3) puncta
abnormal macrophage physiology ( J:261225 )
• unable to translocate LC3 (Map1lc3) to LAP (LC3-associated phagocytosis)-engaged phagosome
• phagocytosis

immune system
abnormal macrophage morphology ( J:261225 )
• increased numbers of LC3 (Map1lc3) puncta
abnormal macrophage physiology ( J:261225 )
• unable to translocate LC3 (Map1lc3) to LAP (LC3-associated phagocytosis)-engaged phagosome
• phagocytosis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory