Phenotypes Associated with This Genotype

Genotype
MGI:6194353

• Allelic Composition: Tg(Myh6-Sumo2*)9592Jwang/0
• Genetic Background: either: B6.FVB-Tg(Myh6-Sumo2*)9592Jwang or (involves: C57BL/6 * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:230540 )

• 36% of mice die within a year after birth

cardiovascular system

cardiac hypertrophy ( J:230540 )

• surviving mice gradually develop cardiac hypertrophy over duration of one year, with increased left ventricle mass/body weight ratio and left ventricular posterior wall end diastole

• however, no impairment in cardiac contractility is seen, indicating a compensatory stage of cardiac hypertrophy

• makers of cardiac disease are elevated

thick ventricular wall ( J:230540 )

• mice exhibit a thickened left ventricle wall and smaller left ventricle cavity

abnormal heart echocardiography feature ( J:230540 )

• mice exhibit surviving mice gradually develop cardiac hypertrophy over duration of one year, with increased left ventricle mass/body weight ratio and left ventricular posterior wall end diastole

growth/size/body

cardiac hypertrophy ( J:230540 )

• surviving mice gradually develop cardiac hypertrophy over duration of one year, with increased left ventricle mass/body weight ratio and left ventricular posterior wall end diastole

• however, no impairment in cardiac contractility is seen, indicating a compensatory stage of cardiac hypertrophy

• makers of cardiac disease are elevated