Phenotypes Associated with This Genotype

Genotype
MGI:6194350

• Allelic Composition: Tg(Myh6-Sumo2*)9610Jwang/0
• Genetic Background: either: B6.FVB-Tg(Myh6-Sumo2*)9610Jwang or (involves: C57BL/6 * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:230540 )

• over 90% of mice die before P90

cardiovascular system

increased myocardial fiber size ( J:230540 )

cardiac hypertrophy ( J:230540 )

abnormal heart left ventricle morphology ( J:230540 )

• mice exhibit increased left ventricular mass/body weight ratio at around P60

cardiac interstitial fibrosis ( J:230540 )

• extensive

decreased cardiac muscle contractility ( J:230540 )

• mice exhibit decreased percent ejection fraction and fractional shortening percentage at around P60

abnormal heart echocardiography feature ( J:230540 )

• mice exhibit increased left ventricular internal diameter, left ventricle diameter systole, left ventricle mass, and decreased percent ejection fraction and fractional shorting percentage

muscle

increased myocardial fiber size ( J:230540 )

decreased cardiac muscle contractility ( J:230540 )

• mice exhibit decreased percent ejection fraction and fractional shortening percentage at around P60

growth/size/body

cardiac hypertrophy ( J:230540 )

cellular

cardiac interstitial fibrosis ( J:230540 )

• extensive