Phenotypes Associated with This Genotype

Genotype
MGI:6192093

• Allelic Composition: Tg(Ela1-Tgfa)150Bri/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreas morphology ( J:52757 )

• 12 of 21 mice show dysplastic changes in the pancreas after 1 year of age

• two types of dysplastic changes are seen: highly proliferating tubular complexes and large cystic changes

abnormal pancreatic acinar cell morphology ( J:52757 )

• decrease in acinar cell height starting at P14

increased pancreas tumor incidence ( J:52757 , J:67389 )

• 4 of 21 mice develop malignant pancreatic tumors which are multicentric and originate from dysplastic tubular complexes and display a mixed cystic-papillary phenotype (J:52757)

• 29% of mice develop malignant pancreatic tumors with a mean tumor-free survival of 410 days (J:67389)

pancreas cyst ( J:52757 )

• some mice show large cystic changes in the pancreas

pancreas fibrosis ( J:52757 )

• an increase in interlobular fibroblast population is seen as early as P14 which progresses to massive fibrosis with extensive extracellular matrix accumulation at P180

pancreatic acinar-to-ductal metaplasia ( J:52757 )

• in older mice, acinar cells change to duct-like cells, which form tubular structures and express ductal markers

neoplasm

increased pancreas tumor incidence ( J:52757 , J:67389 )

• 4 of 21 mice develop malignant pancreatic tumors which are multicentric and originate from dysplastic tubular complexes and display a mixed cystic-papillary phenotype (J:52757)

• 29% of mice develop malignant pancreatic tumors with a mean tumor-free survival of 410 days (J:67389)

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:52757 )

• decrease in acinar cell height starting at P14

growth/size/body

pancreas cyst ( J:52757 )

• some mice show large cystic changes in the pancreas