Phenotypes Associated with This Genotype

Genotype
MGI:6189552

• Allelic Composition: Sephs1^tm1.2Dhat/Sephs1^tm1.2Dhat
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:245139 )

• mice are virtually resorbed by E14.5

embryo

embryonic growth retardation ( J:245139 )

• at E8.5 and E11.5

decreased embryo size ( J:245139 )

• 4-fold smaller than control mice at E11.5 with hypoblastic vestigial organs

abnormal amnion morphology ( J:245139 )

• fused to the yolk sac

growth/size/body

embryonic growth retardation ( J:245139 )

• at E8.5 and E11.5

decreased embryo size ( J:245139 )

• 4-fold smaller than control mice at E11.5 with hypoblastic vestigial organs