Phenotypes Associated with This Genotype

Genotype
MGI:6188976

• Allelic Composition: Scyl1^tm1.1Spel/Scyl1^tm1.1Spel
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

gliosis ( J:262629 )

♂ • in the ventral horn of the spinal cord

decreased motor neuron number ( J:262629 )

♂ • of large motor neurons in the ventral horn of the spinal cord at 8 weeks

motor neuron degeneration ( J:262629 )

♂ • at 8 weeks with Tardbp pathology

abnormal sciatic nerve morphology ( J:262629 )

♂ • reduced number of large caliber axons and total number of myelinated fibers in the sciatic nerve at 8 weeks of age

abnormal myelination ( J:262629 )

♂ • reduced total number of myelinated fibers in the sciatic nerve at 8 weeks of age

muscle

decreased skeletal muscle fiber diameter ( J:262629 )

♂ • reduced cross-sectional area in rectus femoris and bicep brachii at 4 and 8 weeks of age

skeletal muscle atrophy ( J:262629 )

♂ • multifocal neurogenic atrophy of muscles with rectus femoris and bicep brachii most severely affected

behavior/neurological

decreased grip strength ( J:262629 )

♂ • in a mesh gripe test

paralysis ( J:262629 )

♂ • progressive motor dysfunction leading to a paralysis

growth/size/body

postnatal growth retardation ( J:262629 )

♂ • by 3 weeks of age

cellular

gliosis ( J:262629 )

♂ • in the ventral horn of the spinal cord