Analysis Tools
nervous system
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• in the ventral horn of the spinal cord to a greater extent than in Scyl1tm1.1Spel single homozygotes
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• of large motor neurons in the ventral horn of the spinal cord at 4 weeks compared with Scyl1tm1.1Spel single homozygotes
• at 8 weeks compared with wild-type mice
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• at 4 and 8 weeks with Tardbp pathology
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• reduced number of large caliber axons and total number of myelinated fibers in the sciatic nerve at 4 weeks of age
• at 8 weeks compared with wild-type mice
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• reduced total number of myelinated fibers in the sciatic nerve at 4 weeks of age
• at 8 weeks compared with wild-type mice
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growth/size/body
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• compared with either single homozygotes
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• at 8 weeks compared with Scyl1tm1.1Spel single homozygotes
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• by 3 weeks of age
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behavior/neurological
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• progressive motor dysfunction leading to a paralysis that is worse than in Scyl1tm1.1Spel single homozygotes at the same age
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• progressive motor dysfunction leading to a paralysis that is worse than in Scyl1tm1.1Spel single homozygotes at the same age
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muscle
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• reduced cross-sectional area in rectus femoris and bicep brachii at 4 and 8 weeks of age that is more severe at 4 weeks than in Scyl1tm1.1Spel single homozygotes
• at 8 weeks compared with wild-type mice
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cellular
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• in the ventral horn of the spinal cord to a greater extent than in Scyl1tm1.1Spel single homozygotes
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