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Phenotypes Associated with This Genotype
Genotype
MGI:6188648
Allelic
Composition
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Hoxb7-cre)13Amc/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm2Ggg mutation (1 available); any Pkd1 mutation (99 available)
Tg(Hoxb7-cre)13Amc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• apoptosis is increased in kidneys in P7 and P15 mice
• cell proliferation is increased in kidneys in both early and late stage of cystogenesis
• newborn mice exhibit microscopic kidney cysts derived from both cortical and medullary collecting ducts
• P7 kidneys have more and larger cysts, with less parenchyma compared to those in newborns
• by P15, mice present with huge bilateral masses on their flanks and kidneys are grossly cystic with very little normal renal parenchyma
• early and late stage of cystogenesis is associated with increased cell proliferation and increased Cux1 expression while late stage cystogenesis is associated with increased apoptosis and increased Cux1 expression

cellular
• apoptosis is increased in kidneys in P7 and P15 mice
• cell proliferation is increased in kidneys in both early and late stage of cystogenesis

homeostasis/metabolism
• BUN levels are increased at P7 and P15

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
polycystic kidney disease 1 DOID:0110858 OMIM:173900
J:171619


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory