Phenotypes Associated with This Genotype

Genotype
MGI:6188316

• Allelic Composition: Lrrtm1^tm1.1Rmlk/Lrrtm1^tm1.1Rmlk; Lrrtm2^tm1.1Rmlk/Lrrtm2^tm1.1Rmlk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased excitatory postsynaptic current amplitude ( J:263004 )

• reduced AMPAR-EPSCs in mice stereotactically-injected cre-expressing lentivirus into the CA1 region of the hippocampus at P21

• however, NMDAR EPSCs are normal

reduced AMPA-mediated synaptic currents ( J:263004 )

• reduced AMPAR-EPSCs and -mEPSCs in mice stereotactically-injected cre-expressing lentivirus into the CA1 region of the hippocampus at P21

• however, NMDAR EPSCs are normal

reduced long-term potentiation ( J:263004 )

• reduced NMDAR-dependent and -independent LTP in mice stereotactically-injected cre-expressing lentivirus into the CA1 region of the hippocampus at P21

abnormal miniature excitatory postsynaptic currents ( J:263004 )

• decreased amplitude of AMPAR-mediated mEPSCs in mice stereotactically-injected cre-expressing lentivirus into the CA1 region of the hippocampus at P21

• however, mEPSC frequency is normal