Phenotypes Associated with This Genotype

Genotype
MGI:6188064

• Allelic Composition: Ddc^tm1Umon/Ddc^tm1Umon
• Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:250494 )

• decreased latency to fall on rotarod is detected between 11 and 12 weeks of age

abnormal maternal nurturing ( J:250494 )

♀ • homozygous females exhibit poor maternal care

embryo

abnormal embryo development ( J:250494 )

• some E15.5 embryos appear poorly developed

decreased embryo size ( J:250494 )

• some E15.5 embryos appear shriveled

abnormal embryonic tissue morphology ( J:250494 )

• some E15.5 embryos appear grossly dysmorphic

growth/size/body

decreased embryo size ( J:250494 )

• some E15.5 embryos appear shriveled

homeostasis/metabolism

impaired adaptive thermogenesis ( J:250494 )

• mice are sensitive to cold exposure, exhibiting lower body temperatures than controls and a longer recovery period

decreased dopamine level ( J:250494 )

• 25% reduction in dopamine levels in the striatum

• however, dopaminergic cells are not altered in number or morphology

decreased serotonin level ( J:250494 )

• 60% reduction in serotonin levels

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:250494 )

• fewer homozygotes (8%) are produced than expected from a heterozygote x heterozygote mating

reproductive system

reduced female fertility ( J:250494 )

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