Phenotypes Associated with This Genotype

Genotype
MGI:6164158

• Allelic Composition: Braf^tm1Tumg/Braf⁺; Tg(CAG-cre)2Osb/0
• Genetic Background: involves: BALB/c * C57BL * C57BL/6J * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:226977 )

• a few mice survive to adulthood, although all mice die within 24 weeks

postnatal lethality, incomplete penetrance ( J:226977 )

• about 50% of mice die at P5 and 90% at weaning (P28)

growth/size/body

enlarged heart ( J:226977 )

• mice exhibit higher heart weight to body weight ratio at P5, indicating cardiomegaly

postnatal growth retardation ( J:226977 )

cardiovascular system

ostium secundum atrial septal defect ( J:226977 )

• 5 of 6 mice exhibit a large secundum atrial septal defect (ASDII), while 1 of 6 mice exhibit a small ASDII or patent foramen ovale

• however, cardiac valve defects and apparent abnormalities in other tissues are not seen

patent cardiac foramen ovale ( J:226977 )

• 1 of 6 mice exhibit a small ASDII or patent foramen ovale

enlarged heart ( J:226977 )

• mice exhibit higher heart weight to body weight ratio at P5, indicating cardiomegaly

integument

sparse hair ( J:226977 )

ruffled hair ( J:226977 )

liver/biliary system

hepatic necrosis ( J:226977 )

• 36% of mice show liver necrosis at P3

reproductive system

female infertility ( J:226977 )

♀ • females are infertile

♀ • however, males are fertile