Analysis Tools
pigmentation
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• at P8, over half of mice exhibit an area of reduced melanoblasts in the tail unlike in wild-type mice
• however, distribution of melanoblasts in the dermis is normal
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embryo
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• at E18.5/P0, all mice exhibit an area of reduced melanoblasts in the tail compared with just over half of wild-type mice
• at P2, most mice exhibit an area of reduced melanoblasts in the tail compared with few wild-type mice
• at P8, over half of mice exhibit an area of reduced melanoblasts in the tail unlike in wild-type mice
• the boundaries of hypopigmentation are stable over time
• at P28, hypopigmented epidermis in the skin contains no lacZ-positive cells in the scales or hair with some scales at the edge being lightly pigmented and containing less dendritic melanocytes
• however, melanoblast distribution in the tail is normal at E16.5 and distribution of melanoblasts in the dermis is normal
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integument
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• at P8, over half of mice exhibit an area of reduced melanoblasts in the tail unlike in wild-type mice
• however, distribution of melanoblasts in the dermis is normal
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nervous system
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• at E18.5/P0, all mice exhibit an area of reduced melanoblasts in the tail compared with just over half of wild-type mice
• at P2, most mice exhibit an area of reduced melanoblasts in the tail compared with few wild-type mice
• at P8, over half of mice exhibit an area of reduced melanoblasts in the tail unlike in wild-type mice
• the boundaries of hypopigmentation are stable over time
• at P28, hypopigmented epidermis in the skin contains no lacZ-positive cells in the scales or hair with some scales at the edge being lightly pigmented and containing less dendritic melanocytes
• however, melanoblast distribution in the tail is normal at E16.5 and distribution of melanoblasts in the dermis is normal
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