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Phenotypes Associated with This Genotype
Genotype
MGI:6163608
Allelic
Composition
Atp1a3tm1.1Tmklh/Atp1a3+
Genetic
Background
B6JRj.129S1-Atp1a3tm1.1Tmklh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a3tm1.1Tmklh mutation (0 available); any Atp1a3 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at 3 weeks of age

behavior/neurological
N
• mice do not exhibit spontaneous seizures
• in an elevated plus maze, mice do not discriminate between open and closed arms and spend more time in the open arms compared with wild-type mice
• induced by pentylenetetrazole with increased lethality
• mice exhibit reduced latency to re-enter the dark compartment compared with wild-type mice
• however, clonazepam-treatment normalizes performance
• minimal habituation in an open field
• in response to handling
• in the Barnes Maze, mice do not exhibit increased latency to enter the escape tube but walk past the tube multiple times before entering compared with wild-type mice
• in an open field test

nervous system
N
• CA1 pyramidal neurons exhibit normal excitability
• induced by pentylenetetrazole with increased lethality
• large number of pyknotic nuclei within the dentate gyrus granule cell layer
• reduced hippocampal dentate gyrus granule cells
• reduced rate of decay and slower initial discharge rate
• however, mice exhibit normal threshold of induction and steady-state electroresponsive behavior

homeostasis/metabolism

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
alternating hemiplegia of childhood DOID:0050635 OMIM:104290
OMIM:614820
J:254463


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory