Phenotypes Associated with This Genotype

Genotype
MGI:6161738

• Allelic Composition: Sp9^tm1.2Zyan/Sp9^tm1.2Zyan; Tg(Drd2-cre)ER43Gsat/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased locomotor activity ( J:238868 )

• mice exhibited a significant increase in locomotion based on the total distance traveled but no measurable change in anxiety or motor coordination/learning

cellular

increased neuron apoptosis ( J:238868 )

• the striatum of Sp9 conditional mutants had increased numbers of Caspase-3+ cells at P0, P3 and P5

nervous system

increased neuron apoptosis ( J:238868 )

• the striatum of Sp9 conditional mutants had increased numbers of Caspase-3+ cells at P0, P3 and P5

abnormal medium spiny neuron morphology ( J:238868 )

• the striatum of Sp9 conditional mutants had increased numbers of Caspase-3+ cells at P0, P3 and P5

reproductive system

reproductive system phenotype ( J:238868 )

N • mice develop normally and are fertile