Phenotypes Associated with This Genotype

Genotype
MGI:6161736

• Allelic Composition: Sp9^tm1.1Zyan/Sp9^tm1.1Zyan
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

weakness ( J:238868 )

• mutant mice failed to thrive and developed general weakness from P7 onward

cellular

increased neuron apoptosis ( J:238868 )

• mutant null mice lose immature striatopallidal medium-sized spiny neurons due to increased Bax-dependent apoptosis

decreased neuronal precursor proliferation ( J:238868 )

• mutant null mice lose striatopallidal medium-sized spiny neurons due to decreased proliferation of striatopallidal medium-sized spiny neuron progenitors

mortality/aging

postnatal lethality, complete penetrance ( J:238868 )

• mutant mice started to die at P14, and none survived beyond P22

nervous system

increased neuron apoptosis ( J:238868 )

• mutant null mice lose immature striatopallidal medium-sized spiny neurons due to increased Bax-dependent apoptosis

decreased neuronal precursor proliferation ( J:238868 )

• mutant null mice lose striatopallidal medium-sized spiny neurons due to decreased proliferation of striatopallidal medium-sized spiny neuron progenitors

decreased brain weight ( J:238868 )

• brain size and weight of mutant mice are grossly reduced compared to controls at P20

abnormal striatum morphology ( J:238868 )

• atrophy of the striatum

abnormal medium spiny neuron morphology ( J:238868 )

• mutant null mice lose striatopallidal medium-sized spiny neurons due to decreased proliferation of striatopallidal medium-sized spiny neuron progenitors

decreased striatum size ( J:238868 )

• the volume of mutant striatum is reduced to 54% of controls at P9