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Phenotypes Associated with This Genotype
Genotype
MGI:6160757
Allelic
Composition
Plp1tm1c(EUCOMM)Wtsi/Y
Cnptm1(cre)Kan/Cnp+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnptm1(cre)Kan mutation (0 available); any Cnp mutation (19 available)
Plp1tm1c(EUCOMM)Wtsi mutation (0 available); any Plp1 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• density of T-lymphocytes (CD3+ cells) in the fimbria is increased at 26 weeks of age
• microgliosis in the hippocampal fimbria at 26 weeks of age

immune system
• density of T-lymphocytes (CD3+ cells) in the fimbria is increased at 26 weeks of age
• microgliosis in the hippocampal fimbria at 26 weeks of age

nervous system
• microgliosis in the hippocampal fimbria at 26 weeks of age
• hippocampal fimbria exhibits APP+ axonal spheroids, microgliosis and astrogliosis, and increased density of T-lymphocytes
• moderate, but significant, astrogliosis in the hippocampal fimbria at 26 weeks of age
• APP+ axonal spheroids are present in the hippocampal fimbria and corpus callosum at 26 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hereditary spastic paraplegia 2 DOID:0110773 OMIM:312920
J:245100


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory