Phenotypes Associated with This Genotype

Genotype
MGI:6159581

• Allelic Composition: Map2k1^tm2.1Chrn/Map2k1^tm2.1Chrn
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

pulmonary artery stenosis ( J:261678 )

• pulmonary artery stenosis is observed at E13.5

• left and right pulmonary artery lumen areas are reduced

craniofacial

increased cranium length ( J:261678 )

nervous system

increased astrocyte number ( J:261678 )

• increased density of GFAP+ astrocytes is found in sensory cortices and hippocampal CA1

increased oligodendrocyte number ( J:261678 )

• increased density of oligodendrocytes in the sensory cortex

skeleton

increased cranium length ( J:261678 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cardiofaciocutaneous syndrome		DOID:0060233	OMIM:PS115150	J:261678