About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6159076
Allelic
Composition		 Pou2f1tm1Shrp/Pou2f1+
Sox2tm1.1Vep/Sox2+
Genetic
Background		 involves: 129S4/SvJae * C3H/HeN * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2f1tm1Shrp mutation (1 available); any Pou2f1 mutation (98 available)
Sox2tm1.1Vep mutation (0 available); any Sox2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal lens morphology ( J:119175 )
• lens dysmorphology due to reduced Pax6 dosage; degree of dysmorphology is not exacerbated by reduction of Sox2 dosage
• at E12.5, lenses are normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory