Phenotypes Associated with This Genotype

Genotype
MGI:6159075

• Allelic Composition: Pou2f1^tm1Shrp/Pou2f1^tm1Shrp; Sox2^tm1.1Vep/Sox2⁺
• Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

absent nasal placodes ( J:119175 )

endocrine/exocrine glands

abnormal adenohypophysis morphology ( J:119175 )

• mice show dysmorphology of the adenohypophysis

abnormal pituitary diverticulum morphology ( J:119175 )

• dysmorphology is observed in some embryos

nervous system

abnormal adenohypophysis morphology ( J:119175 )

• mice show dysmorphology of the adenohypophysis

abnormal pituitary diverticulum morphology ( J:119175 )

• dysmorphology is observed in some embryos

respiratory system

absent nasal placodes ( J:119175 )

taste/olfaction

absent nasal placodes ( J:119175 )

vision/eye

abnormal lens morphology ( J:119175 )

• at E12.5, lenses are dysmorphic or absent

• peri-ocular region in severely affected animals resembles Pax6^Sey homozygous mice while mildly affected mutants show a similar phenotype to Pax6^Sey heterozygous mice

abnormal eye development ( J:119175 )

• ocular region is not evident at E10.5; ocular region resembles that seen in Pax6^Sey

abnormal lens induction ( J:119175 )

• lens placode induction shows severe defects

microphthalmia ( J:119175 )

• embryos generally exhibit microphthalmia in one eye and anophthalmia in the other

anophthalmia ( J:119175 )

• embryos generally exhibit anophthalmia in one eye and microphthalmia in the other