Phenotypes Associated with This Genotype

Genotype
MGI:6159014

• Allelic Composition: Hspb7^tm1.2Chen/Hspb7^tm1.2Chen; Tg(Myh6-Tmod1)65Msus/Tg(Myh6-Tmod1)65Msus
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

HSPB7 represses formation of abnormal actin bundles independent of Tmod1

cardiovascular system

abnormal fetal cardiomyocyte morphology ( J:256653 )

• at E10.5, average thin filament length was comparable to that observed in cardiomyocytes of single Hspb7^tm1.2Chen homozygotes

muscle

abnormal sarcomere morphology ( J:256653 )

• at E10.5, cardiomyocyte sarcomeres exhibited abnormal actin bundles (AABs) and an average thin filament length that was comparable to that observed in cardiomyocytes of single Hspb7^tm1.2Chen homozygotes, indicating that increasing Tmod1 at pointed ends could not rescue either the AAB or longer thin filament phenotype