Phenotypes Associated with This Genotype

Genotype
MGI:6158942

• Allelic Composition: Scg3^{Gt(VICTR20)13Lex}/Scg3^{Gt(VICTR20)13Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pituitary gland physiology ( J:256077 )

• substantially lower increase in plasma Acth levels after 6 hours of restraint stress daily for 3 weeks

• substantially higher levels of Pomc in pituitary gland after 6 hours of restraint stress daily for 3 weeks

abnormal pancreas physiology ( J:256077 )

• substantially lower insulin level in islets when fed high-fat + high-sucrose (HF/HS) diet

• substantially higher increase in proinsulin level in islets and plasma when fed HF/HS diet

• insulin and proinsulin level in islets when fed normal chow

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:256077 )

N • blood glucose level response after insulin tolerance test (IP insulin challenge) when on normal chow or HF/HS diet

increased susceptibility to diet-induced obesity ( J:256077 )

• substantially more pronounced weight gain when fed high-fat + high-sucrose (HF/HS) diet from age 10 weeks

• when fed standard chow

decreased circulating insulin level ( J:256077 )

• approximately 50% reduction in plasma insulin levels 30 min. after IP glucose challenge when fed high-fat + high-sucrose (HF/HS) diet

• almost no increase in insulin secretion (versus doubling in wild-type) from isolated islets in vitro in high glucose conditions when islets isolated from donors fed HF/HS diet

• insulin secretion from isolated islets in vitro in low glucose conditions when islets isolated from donors fed HF/HS diet

• plasma insulin levels 30 min. after IP glucose challenge when fed normal chow

• insulin secretion from isolated islets in vitro in low and high glucose conditions when islets isolated from donors fed normal chow

impaired glucose tolerance ( J:256077 )

• substantially greater excursions in blood glucose, 15 to 120 minutes after IP glucose challenge when fed high-fat + high-sucrose (HF/HS) diet from age 16 weeks

• when fed standard chow

growth/size/body

increased susceptibility to diet-induced obesity ( J:256077 )

• substantially more pronounced weight gain when fed high-fat + high-sucrose (HF/HS) diet from age 10 weeks

• when fed standard chow

nervous system

abnormal pituitary gland physiology ( J:256077 )

• substantially lower increase in plasma Acth levels after 6 hours of restraint stress daily for 3 weeks

• substantially higher levels of Pomc in pituitary gland after 6 hours of restraint stress daily for 3 weeks

mortality/aging

mortality/aging ( J:256077 )

N • viable

behavior/neurological

behavior/neurological phenotype ( J:256077 )

N • food intake

reproductive system

reproductive system phenotype ( J:256077 )

N • fertile