Phenotypes Associated with This Genotype

Genotype
MGI:6158527

• Allelic Composition: Gripap1^tm1Rlh/Gripap1^tm1Rlh
• Genetic Background: B6.129-Gripap1^tm1Rlh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired active avoidance behavior ( J:256043 )

• shorter step-through latency in light-dark chamber test where mice are introduced in light chamber and had experienced shock during training when crossing into dark chamber

impaired spatial learning ( J:256043 )

• delayed learning of hidden platform location in Morris water maze test

abnormal spatial reference memory ( J:256043 )

• no spatial preference in test where previously introduced platform was removed

nervous system

nervous system phenotype ( J:256043 )

N • long term depression (LTD)

N • paired-pulse ratio (PPR)

reduced long-term potentiation ( J:256043 )

• LTP induction by theta burst stimulation (TBS) results in initially less potentiated field excitatory postsynaptic potential (fEPSP) that remained reduced for at least 1 hr

abnormal miniature excitatory postsynaptic currents ( J:256043 )

• frequency significantly reduced in hippocampal CA1 neurons at age P21-23

• amplitude in hippocampal CA1 neurons at age P21-23