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Phenotypes Associated with This Genotype
Genotype
MGI:6157364
Allelic
Composition
Mmuttm1.1Mrb/Mmuttm1.1Mrb
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmuttm1.1Mrb mutation (0 available); any Mmut mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit elevated glycine levels in blood
• however, other amino acid levels are mostly unchanged

growth/size/body
• mice fed a high protein (HP) diet or a precursor-enriched (PE) diet comprised of increased levels of precursor amino acids of propionate pathway metabolites exhibit a rapid weight loss, with more pronounced weight loss of the PE diet
• mice fed a high protein diet and treated with cobalamin do no show weight loss
• mice show significant growth retardation after the age of about 100 days in females and about 150 days in males

homeostasis/metabolism
• propionylcarnitine (normalized to acetylcarnitine) in blood is elevated, although to a lower extent than in compound heterozygous Muttm1Pai/Muttm1.1Mrb mice
• mice fed a HP or PE diet show further elevations in propionylcarnitine levels
• mice fed a HP diet and treated with cobalamin show delayed elevations in propionylcarnitine
• mice exhibit elevated glycine levels in blood
• however, other amino acid levels are mostly unchanged
• mice fed a HP or PE diet show increased ammonia levels, indicative of metabolic crisis induction
• however, mice fed a regular chow diet exhibit normal ammonia levels
• mice fed a HP diet and treated with cobalamin exhibit delayed elevation of ammonia
• mice exhibit increased levels of odd chain fatty acids in plasma, predominantly of the 13-carbon chain length fatty acid
• however, levels of even chain fatty acids are normal
• methylmalonic acid is elevated in tissues and dried blood, although to a lower extent than in compound heterozygous Muttm1Pai/Muttm1.1Mrb mice
• mice fed a HP or PE diet show further elevations in methylmalonic acid levels
• methylmalonic acid levels are elevated in urine, although to a lower extent than in compound heterozygous Muttm1Pai/Muttm1.1Mrb mice
• mice fed a HP or PE diet show further elevations in methylmalonic acid levels

renal/urinary system
• methylmalonic acid levels are elevated in urine, although to a lower extent than in compound heterozygous Muttm1Pai/Muttm1.1Mrb mice
• mice fed a HP or PE diet show further elevations in methylmalonic acid levels

mortality/aging
N
• mice exhibit a normal life span


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory