Phenotypes for Sec22b Tg(Itgax-cre)1-1Reiz MGI:6156916 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Sec22b^{tm1c(EUCOMM)Wtsi}/Sec22b^{tm1c(EUCOMM)Wtsi} Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: C57BL/6 * C57BL/6N * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec22b^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Sec22b mutation (15 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:255769 )

• development of dendritic cell (DC), myeloid cell, T cell and other lymphoid populations, and thymocyte differentiation and T cell activation state

• dendritic cell (DC) development, cytokine response to toll-like receptor (Tlr) stimulation, direct antigen presentation, and endocytic antigen uptake

• in vivo cross-presentation of soluble antigens

• in vitro cross-presentation of soluble or particulate antigens using splenic Cd11c+ DCs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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