Analysis Tools
craniofacial
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• although there is monoallelic expression of this substution allele and the expressed receptor responds to its specific agonist, Ro27-3225, but not OLFR151 agonists, 32% of the olfactory sensory neurons expressing this allele have an immature phenotype, being OMP negative and GAP43 positive
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• compared with GFP-tagged endogenous olfactory receptor 151 homozygotes, which show expression on 2928 +/- 152 olfactory sensory neurons, only 1013 +/- 92 olfactory sensory neurons express this substitution allele, and the glomeruli they form are much smaller than those formed by normal OLFR151-expressing olfactory sensory neurons
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growth/size/body
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• although there is monoallelic expression of this substution allele and the expressed receptor responds to its specific agonist, Ro27-3225, but not OLFR151 agonists, 32% of the olfactory sensory neurons expressing this allele have an immature phenotype, being OMP negative and GAP43 positive
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• compared with GFP-tagged endogenous olfactory receptor 151 homozygotes, which show expression on 2928 +/- 152 olfactory sensory neurons, only 1013 +/- 92 olfactory sensory neurons express this substitution allele, and the glomeruli they form are much smaller than those formed by normal OLFR151-expressing olfactory sensory neurons
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nervous system
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• although there is monoallelic expression of this substution allele and the expressed receptor responds to its specific agonist, Ro27-3225, but not OLFR151 agonists, 32% of the olfactory sensory neurons expressing this allele have an immature phenotype, being OMP negative and GAP43 positive
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• compared with GFP-tagged endogenous olfactory receptor 151 homozygotes, which show expression on 2928 +/- 152 olfactory sensory neurons, only 1013 +/- 92 olfactory sensory neurons express this substitution allele, and the glomeruli they form are much smaller than those formed by normal OLFR151-expressing olfactory sensory neurons
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respiratory system
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• although there is monoallelic expression of this substution allele and the expressed receptor responds to its specific agonist, Ro27-3225, but not OLFR151 agonists, 32% of the olfactory sensory neurons expressing this allele have an immature phenotype, being OMP negative and GAP43 positive
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• compared with GFP-tagged endogenous olfactory receptor 151 homozygotes, which show expression on 2928 +/- 152 olfactory sensory neurons, only 1013 +/- 92 olfactory sensory neurons express this substitution allele, and the glomeruli they form are much smaller than those formed by normal OLFR151-expressing olfactory sensory neurons
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taste/olfaction
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• although there is monoallelic expression of this substution allele and the expressed receptor responds to its specific agonist, Ro27-3225, but not OLFR151 agonists, 32% of the olfactory sensory neurons expressing this allele have an immature phenotype, being OMP negative and GAP43 positive
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• compared with GFP-tagged endogenous olfactory receptor 151 homozygotes, which show expression on 2928 +/- 152 olfactory sensory neurons, only 1013 +/- 92 olfactory sensory neurons express this substitution allele, and the glomeruli they form are much smaller than those formed by normal OLFR151-expressing olfactory sensory neurons
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