Phenotypes Associated with This Genotype

Genotype
MGI:6153997

• Allelic Composition: Sucla2^{Gt(IST10208H1)Tigm}/Sucla2⁺; Suclg2^{Gt(Ayu21-KBW131)Imeg}/Suclg2⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased mitochondrial DNA content ( J:241325 )

• in mitochondria from liver and brain of 12-months old mice

decreased hepatocyte mitochondrial DNA content ( J:241325 )

abnormal oxidative phosphorylation ( J:241325 )

• significant decrease in ATP-generating activity in mitochondria from heart and brain of 12-months old mice

• significant increase in succinate dehydrogenase (electron transport chain) activity in mitochondria from heart of 12-months old mice

• ATP-generating activity in mitochondria from liver of 12-months old mice

• GTP-generating activity in mitochondria from liver, heart and brain of 12-months old mice

liver/biliary system

decreased hepatocyte mitochondrial DNA content ( J:241325 )

homeostasis/metabolism

increased circulating carnitine level ( J:241325 )

• increased levels of some carnitine esters in blood