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Phenotypes Associated with This Genotype
Genotype
MGI:6151155
Allelic
Composition		 Atg7tm1Tchi/Atg7tm1Tchi
Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (39 available)
Atg7tm1Tchi mutation (3 available); any Atg7 mutation (51 available)
Cnot3tm1.1Kjkb mutation (0 available); any Cnot3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:260012 )
• tamoxifen-treated mice survive until P40

cardiovascular system
decreased cardiac muscle contractility ( J:260012 )
• not as severe as in mice Cnot3tm2.1Tya A1cfTg(Myh6-cre/Esr1*)1Jmk mice

muscle
decreased cardiac muscle contractility ( J:260012 )
• not as severe as in mice Cnot3tm2.1Tya A1cfTg(Myh6-cre/Esr1*)1Jmk mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory