Phenotypes Associated with This Genotype

Genotype
MGI:6151053

• Allelic Composition: Mirc40^tm1Jzb/Mirc40^tm1Jzb
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina blood vessel morphology ( J:244554 )

• thinned at P30 and P120

abnormal retina cone cell morphology ( J:244554 )

• impaired nuclear polarization during development with nuclei retracting to the inner part at P10 and remain on the basal part of the outer nuclear layer at P180

short retina cone cell outer segment ( J:244554 )

• short

abnormal retina outer nuclear layer morphology ( J:244554 )

thin retina outer nuclear layer ( J:244554 )

• progressive from P30 to P180

• however, the inner nuclear layer is normal in thickness

abnormal cone electrophysiology ( J:244554 )

• photopic a- and b-waves are abolished as early as P30 continuing at P120 and P180

abnormal rod electrophysiology ( J:244554 )

• scotopic b-wave amplitude decreases at P30 and further at P180

• scotopic a-wave amplitudes are decreased at P30, P120 and P180

cardiovascular system

abnormal retina blood vessel morphology ( J:244554 )

• thinned at P30 and P120

immune system

increased microglial cell activation ( J:244554 )

• in the outer nuclear layer

nervous system

increased microglial cell activation ( J:244554 )

• in the outer nuclear layer

abnormal retina cone cell morphology ( J:244554 )

• impaired nuclear polarization during development with nuclei retracting to the inner part at P10 and remain on the basal part of the outer nuclear layer at P180

short retina cone cell outer segment ( J:244554 )

• short

hematopoietic system

increased microglial cell activation ( J:244554 )

• in the outer nuclear layer

cellular

increased microglial cell activation ( J:244554 )

• in the outer nuclear layer