Phenotypes for Edil3 Strip1 MGI:6121353 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Strip1^{tm1b(KOMP)Wtsi}/Strip1^{tm1c(KOMP)Wtsi} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: C57BL/6N * CBA * FVB/NJ * SJL
Cell Lines	EPD0316_1_G03

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (44 available)
Strip1^{tm1b(KOMP)Wtsi} mutation (0 available); any Strip1 mutation (42 available)
Strip1^{tm1c(KOMP)Wtsi} mutation (0 available); any Strip1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:251816 )

N	• unlike Strip1^cin homozygotes, mice do not exhibit the constriction around the embryonic and extraembryonic tissue boundary, defects in cell proliferation, and organization and polarity of neural and epithelium

abnormal mesoderm development ( J:251816 )

• nascent mesoderm fails to move away from the primitive streak and accumulates in the midline ridge

short rostral-caudal axis ( J:251816 )

• extremely shortened anterior-posterior axis lacking a trunk section at E8.5

abnormal head fold morphology ( J:251816 )

cardiovascular system

cardia bifida ( J:251816 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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