Phenotypes Associated with This Genotype

Genotype
MGI:6120563

• Allelic Composition: Gt(ROSA)26Sor^{tm1.1(DUX4*)Plj}/Gt(ROSA)26Sor⁺; Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired righting response ( J:256652 )

• pups lose the righting reflex between 5-12 weeks of age

tremors ( J:256652 )

• between 5-12 weeks of age pups develop tremors

ataxia ( J:256652 )

• between 5-12 weeks of age pups develop progressive ataxia

seizures ( J:256652 )

• pups develop spontaneous seizures characterized by periods of wild and uncontrolled running by 12 weeks of age

immune system

enlarged lymph nodes ( J:256652 )

• swollen subiliac lymph nodes

enlarged popliteal lymph nodes ( J:256652 )

integument

alopecia ( J:256652 )

• P10 pups exhibit mild alopecia by 3 weeks, progressing to severe alopecia by 12 weeks of age

retarded hair growth ( J:256652 )

• pups exhibit delayed fur growth at P10

nervous system

seizures ( J:256652 )

• pups develop spontaneous seizures characterized by periods of wild and uncontrolled running by 12 weeks of age

skeleton

kyphosis ( J:256652 )

• between 5-12 weeks of age pups develop severe kyphosis