mortality/aging
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• pups are stillborn and small
• pups develop until almost full term (E19.5)
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limbs/digits/tail
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• E16.5 embryos exhibit deformed limbs
|
growth/size/body
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• observed in E16.5 embryos
|
nervous system
|
• E16.5 embryos exhibit aberrant spinal columns
|
skeleton
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• E16.5 embryos exhibit underdeveloped rib cages
|


Analysis Tools