Phenotypes Associated with This Genotype

Genotype
MGI:6120560

• Allelic Composition: Gt(ROSA)26Sor^{tm1.1(DUX4*)Plj}/Gt(ROSA)26Sor^{tm1.1(DUX4*)Plj}
• Genetic Background: B6(Cg)-Gt(ROSA)26Sor^{tm1.1(DUX4*)Plj}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

rectal prolapse ( J:256652 )

• some mice develop rectal prolapse after 6 months of age

abnormal defecation ( J:256652 )

• soft stools

endocrine/exocrine glands

preputial gland inflammation ( J:256652 )

♂ • males develop an inflamed preputial gland

growth/size/body

decreased body weight ( J:256652 )

• adult mice are smaller than controls; weight gain peaks at 9 weeks and plateaus at 21-23 grams

• adults are 43% smaller than wild-type and 33% smaller than heterozygotes

• males are smaller from birth

integument

alopecia ( J:256652 )

• alopecia is more severe than in hemizygous mutant mice

• alopecia appears between 3-8 weeks of age

muscle

muscle phenotype ( J:256652 )

N • mice exhibit no overt myopathy

reproductive system

preputial gland inflammation ( J:256652 )

♂ • males develop an inflamed preputial gland

immune system

preputial gland inflammation ( J:256652 )

♂ • males develop an inflamed preputial gland